About Trimethylaminuria

Primary Trimethylaminuria, also known as tmauria, is related to trimethylaminuria and abdominal obesity-metabolic syndrome 1. An important gene associated with Primary Trimethylaminuria is FMO3 (Flavin Containing Dimethylaniline Monoxygenase 3). Affiliated tissues include liver, skin and brain.

Major Symptoms of Trimethylaminuria

Trimethylaminuria is a rare hereditary metabolic disease. The main symptoms include:

1. Uraciluria syndrome: patients will suffer from severe oliguria, anuria and renal failure. This is Uraciluria syndrome affects the reabsorption of uracil and uric acid by the renal tubules, resulting in large amounts of uracil and uric acid being excreted in the urine.

2. Skin damage: The patient's skin may develop erythema, papules, and skin ulcers. These symptoms are usually worsened after exposure to sunlight or ultraviolet radiation.

3. Oral problems: Patients may experience dry mouth, oral ulcers, and gingivitis, which may lead to loose teeth and gum recession.

4. Feeding difficulties: Because patients’ digestive systems are affected, they may experience feeding difficulties and gastrointestinal disorders.

5. Psychiatric problems: Some patients may develop mental disorders such as anxiety, depression, and difficulty concentrating.

6. Blood problems: Patients may develop anemia, leukopenia, and thrombocytopenia, which may lead to an increased risk of infection and bleeding.

7. Nervous system problems: Patients may experience neurological problems such as headaches, dizziness and epilepsy.

8. Congenital anorectal stenosis: Some patients may develop anorectal stenosis, which may cause constipation and difficulty defecation.

9. Hearing problems: Some patients may experience hearing loss, which may be due to uraciluria syndrome, which affects blood circulation in the inner ear. Trimethylaminuria is a complex genetic disorder and symptoms and disease progression may vary among patients. If you have relevant symptoms or concerns, it is recommended that you consult a professional doctor for evaluation and diagnosis.

Suitable Lifestyle for People with Trimethylaminuria

Trimethylaminuria is a hereditary amino acid metabolism disease. Patients have an abnormality in amino acid metabolism, resulting in large amounts of nitrogen-containing substances in the urine. Therefore, patients with trimethylaminuria should avoid consuming high-nitrogen foods to avoid worsening symptoms. In terms of diet, patients should follow their doctor's recommendations and control their protein and nitrogen intake. The diet should be low in nitrogen, low in fat, high in fiber, and rich in vitamins and minerals. It is recommended that patients eat more vegetables, fruits, whole grains, low-fat protein foods, etc. , while avoiding foods high in fat, sugar, and salt. In addition, patients should avoid bad habits such as alcoholism and overeating, maintain a good work and rest routine, and strengthen exercise to maintain good health. In short, for patients with Trimethylaminuria, the diet should be low in nitrogen, low in fat, high in fiber, rich in vitamins and minerals, and they should also pay attention to developing good living habits.

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