About Castleman Disease

Castleman Disease, also known as angiofollicular ganglionic hyperplasia, is related to multicentric castleman disease and polyclonal hypergammaglobulinemia. An important gene associated with Castleman Disease is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Thalidomide and Zanubrutinib have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone marrow and bone, and related phenotypes are fatigue and anemia

Major Symptoms of Castleman Disease

Castleman disease is a rare autoimmune disorder characterized by progressive lymph node swelling, itching, and worsening of skin rash. The symptoms may include swollen lymph nodes, itching, hives, and rashes on the skin.

Suitable Lifestyle for People with Castleman Disease

Castleman disease is a rare disease in which the immune system overreacts, causing damage to skin and internal organs throughout the body. Life styles that people with Castleman disease need to pay attention to include:

1. Avoid exposure to the sun: Ultraviolet rays in the sun can stimulate the immune system to overreact and aggravate disease symptoms.

2. Keep your skin clean and moisturized: Castleman disease may cause dry, rough skin that is prone to itching and inflammation. You need to pay attention to keeping your skin clean and moisturized.

3. Eat a balanced diet: Eat more fresh fruits, vegetables, whole grains and protein-rich foods, and avoid foods high in sugar, fat and salt.

4. Control weight: Being overweight will increase the burden on the immune system and reduce disease symptoms.

5. Avoid infection: The immune system of patients with Castleman disease is susceptible to infection and they need to pay attention to preventing infection.

6. Regular exercise: Moderate aerobic exercise can improve immunity and reduce disease symptoms.

7. Maintain a good attitude: A positive attitude can enhance immune system function and reduce disease symptoms.

Other Diseases

Idiopathic Multicentric Castleman DiseaseStill DiseaseFarber DiseaseWilson's DiseaseFahr DiseaseOllier DiseaseFabry's DiseaseTay-Sachs DiseaseMoyamoya DiseaseHartnup DiseaseWagner DiseaseMenkes DiseaseCanavan DiseaseSchamberg DiseaseWolman DiseaseDupuytren DiseaseGaucher DiseaseStargardt DiseaseGraves DiseaseWhipple's Disease