About High Molecular Weight Kininogen Deficiency

High Molecular Weight Kininogen Deficiency, also known as hmwk deficiency, is related to factor xi deficiency and thrombosis. An important gene associated with High Molecular Weight Kininogen Deficiency is KNG1 (Kininogen 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include prostate, breast and salivary gland, and related phenotypes are prolonged partial thromboplastin time and reduced kininogen activity

Major Symptoms of High Molecular Weight Kininogen Deficiency

High molecular weight kininogen deficiency is a rare genetic disease. The main symptoms include:

1. Hypertension: Patients may have sustained hypertension, which may be related to vasodilation caused by kinin deficiency. .

2. Proteinuria: This disease is often accompanied by damage to the glomerular filtration membrane, leading to proteinuria.

3. Vision problems: High-molecular-mass kinins play a key role in the retina, so patients may develop vision problems, including blurred vision, nighttime vision loss, and macular degeneration.

4. Skin problems: Patients may experience skin symptoms such as dry skin, flakes, rashes and itching.

5. Digestive problems: Patients may experience digestive problems such as diarrhea, constipation and bloating.

6. Nervous problems: High molecular weight kinins play a key role in the nervous system, so patients may experience neurological problems such as headaches, dizziness and insomnia.

7. Heart problems: Patients may develop heart problems such as palpitations, irregular heartbeat, and heart failure. It should be noted that these symptoms may not occur in all patients, and the specific situation needs to be judged based on individual differences. If you have these symptoms, it is recommended to seek medical treatment promptly for more professional diagnosis and treatment.

Suitable Lifestyle for People with High Molecular Weight Kininogen Deficiency

High molecular weight kininogen deficiency is a rare genetic disease in which patients have abnormal function of the vascular endothelial growth factor receptor 2 (VEGFR2) gene due to genetic mutations. Mutations in the vascular endothelial growth factor receptor 2 gene can cause vascular endothelial growth factor receptor 2 Abnormal expression of the gene, resulting in vascular endothelial growth factor receptor 2 gene defects. There is currently no specific treatment for this disease, so patients need to pay special attention to their lifestyle. The following are some suitable lifestyles for people with high molecular weight kininogen deficiency:

1. Maintain a healthy lifestyle: Patients need to avoid unhealthy lifestyles, such as smoking, drinking, overeating, etc. , maintain a regular schedule, and strengthen exercise , maintain a good mental state.

2. Avoid infection: Infection is one of the main causes of death in patients with high molecular weight kininogen deficiency. Patients need to avoid infections such as colds, flu, diarrhea, etc.

3. Follow the doctor's advice: Patients need to closely follow the doctor's advice, take medicine on time, receive regular examinations, and adjust treatment plans in a timely manner.

4. Strengthen nutrition: Patients need to strengthen nutrition, eat more fresh fruits, vegetables, whole grains, high-quality protein, vitamins and minerals, etc. , and avoid high-fat, high-calorie, high-salt diets.

5. Maintain a good attitude: Patients need to maintain a good attitude, avoid excessive anxiety, pessimism and other negative emotions, communicate more with family and friends, and seek psychological support.

6. Regular exercise: Patients need to exercise regularly, such as walking, jogging, swimming, etc. Exercise can enhance the body's immunity and improve the condition.

7. Maintain social activities: Patients need to maintain social activities, participate in more activities in the community, relatives and friends, and establish good relationships with others, which is conducive to disease recovery and mental health.

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