About Meleda Disease

Mal De Meleda, also known as meleda disease, is related to palmoplantar keratosis and erythrokeratodermia variabilis et progressiva 1. An important gene associated with Mal De Meleda is SLURP1 (Secreted LY6/PLAUR Domain Containing 1), and among its related pathways/superpathways are Post-translational modification: synthesis of GPI-anchored proteins and Burn wound healing. Affiliated tissues include skin and heart, and related phenotypes are palmoplantar keratoderma and superficial dermal perivascular inflammatory infiltrate

Major Symptoms of Meleda Disease

Meleda disease, also known as Melendiak-Savon disease, is a rare autoimmune disorder that primarily affects the liver and kidneys. The major symptoms include progressive liver damage, proteinuria, hematuria, jaundice, hepatomegaly, and hepatic insufficiency. In addition, Meleda disease can also cause joint pain, skin rashes, and a characteristic late-onset fever.

Suitable Lifestyle for People with Meleda Disease

A suitable lifestyle for people with Meleda disease may include the following:

1. Maintain good living habits, including adequate sleep, a balanced diet and appropriate exercise;

2. Avoid exposure to harmful environments, such as PM2. 5 , formaldehyde, etc. ;

3. Maintain a good attitude and avoid excessive anxiety, pessimism and other negative emotions;

4. Learn some self-regulation techniques, such as meditation, yoga, etc. , to help regulate your mood;

5. Connect with other people suffering from Meleda disease Build connections and share each other's experiences and emotions to enhance psychological support.

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