About Familial Juvenile Hyperuricemic Nephropathy

Tubulointerstitial Kidney Disease, Autosomal Dominant, 1, also known as familial juvenile hyperuricemic nephropathy, is related to nephronophthisis and hyperuricemic nephropathy, familial juvenile, 3. An important gene associated with Tubulointerstitial Kidney Disease, Autosomal Dominant, 1 is UMOD (Uromodulin), and among its related pathways/superpathways are "Uricosurics Pathway, Pharmacodynamics" and "Allopurinol Pathway, Pharmacokinetics". Affiliated tissues include kidney, liver and bone, and related phenotypes are renal insufficiency and hyperuricemia

Major Symptoms of Familial Juvenile Hyperuricemic Nephropathy

Familial Juvenile Hyperuricmic Nephropathy (FJHN) is a hereditary kidney disease. Its main symptoms include:

1. High blood pressure: Patients with FJHN often develop high blood pressure, which can cause damage to the kidneys.

2. Proteinuria: FJHN patients will suffer from glomerular filtration membrane damage, leading to proteinuria.

3. Hematuria: The presence of protein and red blood cells in the blood may indicate damage to the glomerular filtration membrane.

4. Decreased glomerular filtration rate: The glomerular filtration rate of FJHN patients is lower than that of normal people, leading to abnormal renal function.

5. Edema: Patients with FJHN may develop edema, especially in the face and lower extremities.

6. Abnormal renal function: FJHN patients often have abnormal renal function, such as elevated serum creatinine.

7. Hereditary: FJHN is a hereditary disease and patients may inherit it from their parents or other close relatives.

Suitable Lifestyle for People with Familial Juvenile Hyperuricemic Nephropathy

Suitable lifestyle options for people with Familial Juvenile Hyperuricmic Nephropathy include the following:

1. Maintain good eating habits. Avoid foods high in purine, sodium, and fat, and eat more fiber-rich foods such as vegetables, fruits, and whole grains to maintain a balanced diet.

2. Get regular physical exercise. Exercise can help reduce symptoms, enhance immunity, and reduce urate deposition. It is recommended to do at least 150 minutes of aerobic exercise every week, such as brisk walking, jogging, cycling, etc.

3. Develop a regular sleep schedule. Ensure adequate sleep time and avoid staying up late. Developing good work and rest habits and ensuring adequate sleep time can help reduce symptoms.

4. Avoid overexertion. Overexertion will aggravate the condition and affect the effect of treatment.

5. Maintain a good attitude. Maintaining a good attitude and avoiding negative emotions such as anxiety and depression can help reduce symptoms.

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